Burn More Calories Than You Eat
There are so many people who tell you that this or that is the key to weight loss but if you burn more calories than you take in I guarantee you will lose weight. Now, I didn't say it was easy but generally speaking you will get down to the weight you want.
How do you do it? Well a good start is exercising often, whether it's on the treadmill or just taking walks around your house, exercise is always the easiest way. If you're too busy, or just don't want to exercise a diet like Medifast would do the job because it's very low calorie and simple to follow, just expensive though so not for everyone.
Bottom line, burn more calories and/or eat less calories and you'll do fine.
Exercise Is Key
Just like I said above, YOU NEED TO EXERCISE!
There is really no getting around it unless you want to eat nothing but lettuce the rest of your life you need to get off the couch and do something. If you can't do than then I really don't know what to tell you because you lead way too busy a life.
For the rest of us just go out and do something and get off your butt. You don't have to lift weights like a meat head in a gym, just getting out and about is usually good enough. If you have a lot of weight to lose then you need to exercise more. Don't worry when you start getting down to the weight you want you can slow down a little on the frequency of exercise.
Stop Eating Junk
We eat way too much junk food. I don't care who you are, you probably eat way too much just like me. Cut back the junk food to a few times a week or less and you will probably lose weight. Drink a lot of soda? Eat a lot of sugar? Yea, there's your problem, and fatty foods like burgers and fries are worse because they clog your arteries as well. Cut back on the junk food and you'll lose weight, guaranteed.
So that's pretty much it, the three magical keys to weight loss. You didn't even need the Mayo Clinic to do a study to prove it! If you want to send me four easy payments of $100 each like all those TV infomercials that offer the same thing then I won't argue, but if you're serious about losing weight that's all you need to do, so what are you waiting for? Get out there and do it!